anti-PARP-10 [ARTD10] (human), mAb (5H11)-单抗-深圳欣博盛生物科技有限公司

首页产品中心单抗

anti-PARP-10 [ARTD10] (human), mAb (5H11)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-20T-0004-L001

规格：1 ml

目录价：￥3840

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-PARP-10 [ARTD10] (human), mAb (5H11)

别名:

ADP-ribosyltransferase Diphtheria Toxin-like 10; Poly(ADP-ribose) Polymerase-10

产品描述:

PARP-10 [ARTD10] is a mono-ADP-ribosyltransferase and was initially identified as an interaction partner of the proto-oncoprotein Myc. PARP-10 possesses ubiquitin-interaction motifs, which are important to inhibit the activation of NF-kappaB and downstream target genes in response to interleukin-1beta [IL-1beta] and tumor necrosis factor-alpha [TNF-alpha]. PARP-10 mono(ADP-ribosyl)ates (MARylates) NEMO (NF-kappaB essential modulator), which results in reduced NEMO polyubiquitylation and thus decreased NF-kappaB signaling. Overexpression of PARP-10 was shown to lead to apoptosis. PARP-10 knockdown leads to increased cell survival. Additional substrates of PARP-10, such as GSK-3beta were identified and PARP-10-mediated mono(ADP-ribosyl)ation (MARylation) was shown to be involved in regulating multiple processes, including Wnt signaling.

实验应用:

ICC, IP, WB

靶标/特异性:

Recognizes human PARP-10 [ARTD10] with an epitope between aa 256-407, containing the glycine rich (G-rich) region.

同种型:

Rat IgG1

免疫原:

Recombinant human PARP-10 [ARTD10] (aa 1-907) fused to a GST-tag.

克隆号:

5H11

保存温度:

+4°C