anti-Survival Motor Neuron Protein, mAb (7B10)-单抗-深圳欣博盛生物科技有限公司

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anti-Survival Motor Neuron Protein, mAb (7B10)

品牌：Adipogen

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说明书

折扣/货期

货号：AG-20T-0003-C200

规格：200 ug

目录价：￥5400

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Survival Motor Neuron Protein, mAb (7B10)

别名:

SMN; Gemin-1; Component of Gems 1; BCD541

产品描述:

The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. It is expressed in a wide variety of tissues, including high levels in brain, kidney and liver, moderate levels in skeletal and cardiac muscle and low levels in fibroblasts and lymphocytes. Mutations in SMN cause spinal muscular atrophy 1 (SMA1). Spinal muscular atrophy is a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. The antibody was used extensively to purify and characterize the macromolecular SMN complex from cultured human cells. The antibody binds with high affinity and specificity to its epitope, which comprises a sequence of up to 9 amino acids in the N-terminal part of human SMN. It allows the native elution of bound antigen with an excess of the cognate peptide. Via addition of the 7B10 epitope (TagIt epitope) to other proteins this purification strategy can also be exploited for purification of these fusion proteins and RNA-protein complexes from cells lacking this epitope on endogenous proteins, such as cells derived from C. elegans and Drosophila.

实验应用:

IP, WB

靶标/特异性:

Recognizes a sequence of up to 9 amino acids in the N-terminal domain of human SMN.

同种型:

Mouse IgG1

免疫原:

Recombinant human full-length survival motor neuron protein (SMN).

克隆号:

7B10

产品浓度:

2mg/ml