anti-PD-L1 (human), mAb (AG-IHC411)-单抗-深圳欣博盛生物科技有限公司

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anti-PD-L1 (human), mAb (AG-IHC411)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-20B-6022-R100

规格：100 ul

目录价：￥2040

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-PD-L1 (human), mAb (AG-IHC411)

别名:

PD-L1; Programmed Death Ligand 1; PDCD1 Ligand 1; CD274; B7-H1; B7 Homolog 1

产品描述:

Programmed death ligand 1 (PD-L1, B7-H1 or CD274) is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. PD-L1 is a transmembrane protein involved in suppressing the immune system and rendering tumor cells resistant to CD8+ T cell-mediated lysis through binding of the Programmed Death-1 (PD-1) receptor. PD-L1 is widely expressed in several organs such as heart, skeletal muscle, placenta and lung, and in lower amounts in thymus, spleen, kidney and liver. Overexpression of PD-L1 may allow cancer cells to evade the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumor aggressiveness and risk of death, and, in ovarian cancer, higher expression of this protein has lead to significantly poorer prognosis. PD-L1 has also been linked to systemic lupus erythematosus and cutaneous melanoma. When considered in adjunct with CD8+ tumor-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small cell lung cancer, hormone receptor negative breast cancer and sentinel lymph node melanoma. This antibody is intended to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed, paraffin-embedded tissue sections using IHC test methods. It has been optimized and validated using the BOND-MAX fully automated IHC&ISH stainer (see Protocol).

宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.

实验应用:

ELISA, IHC

靶标/特异性:

Recognizes human PD-L1 (CD274).

同种型:

Rabbit IgG

免疫原:

Recombinant human PD-L1.

克隆号:

AG-IHC411