anti-Periostin, mAb (blocking) (OC-20) (preservative free)-单抗-深圳欣博盛生物科技有限公司

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anti-Periostin, mAb (blocking) (OC-20) (preservative free)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-20B-6000YPF-C100	规格：100 ug	目录价：￥5040
货号：AG-20B-6000YPF-C500	规格：500 ug	目录价：￥20400

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Periostin, mAb (blocking) (OC-20) (preservative free)

别名:

Osteoblast-specific Factor 2; OSF-2; Postn

产品描述:

Periostin is a 90-kDa matricellular protein that consists of a typical signal sequence, followed by a cysteine-rich region, an EMI domain (protein-protein interactions), four tandem fasciclin-like domains that are responsible for integrin binding, and a C-terminal region. Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and in osteoblast recruitment, attachment and spreading. Periostin is also involved in many fundamental biological processes such as cell proliferation, cell invasion and angiogenesis. Periostin expression is increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2). Changes in periostin expression are commonly detected in various cancers and pre-cancerous conditions, and periostin may be involved in regulating cancer cell activities that contribute to tumorigenesis, cancer progression and metastasis. Periostin has shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype and increased expression of inflammatory mediators. It is evaluated as a biomarker for bronchial asthma and airway inflammation.

宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.

实验应用:

FUNC (Blocking), ICC

靶标/特异性:

Recognizes human and mouse periostin. Detects the FAS1-2 domain of periostin at a new binding site for the integrins alphavbeta3 and alphavbeta5.

同种型:

Mouse IgMkappa

免疫原:

Recombinant fragments of human periostin.

克隆号:

OC-20