anti-Fibronectin (EDA), mAb (blocking) (IST-9) (preservative free)-单抗-深圳欣博盛生物科技有限公司

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anti-Fibronectin (EDA), mAb (blocking) (IST-9) (preservative free)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-20B-6001YPF-C100	规格：100 ug	目录价：￥3360
货号：AG-20B-6001YPF-C500	规格：500 ug	目录价：￥8280

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-Fibronectin (EDA), mAb (blocking) (IST-9) (preservative free)

别名:

FN; Cold-insoluble Globulin; CIG; Fibronectin (EIIIA)

产品描述:

Fibronectin is a major component of the extracellular matrix that binds to integrins, cell surfaces and various compounds including collagen, fibrin, heparin, DNA and actin. It occurs in two main forms: plasma and cellular fibronectin. EDA (Extra Domain A)-containing cellular fibronectin (EDA-FN) plays a major role in cell adhesion, growth, migration and differentiation and it is important for processes such as wound healing and embryonic development. It is associated with fibroblast differentiation by increasing alpha-SMA expression, collagen deposition, cell contractility and focal adhesion kinase (FAK) activation. EDA-FN promotes cell spread by interacting with the integrins alpha5-beta1, alpha4-beta1 and alpha9-beta1 and has been shown to promote angiogenesis, lymphangiogenesis and metastasis of colorectal tumors. In transformed or tumor-derived cells the EDA segment is about 10-times higher than in fibronectin from normal fibroblasts and it may therefore be a significant marker for malignancy.

宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.

实验应用:

ELISA, FUNC (Blocking), ICC, IHC, WB

靶标/特异性:

Recognizes an epitope located in the EDA sequence of human cellular fibronectin (FN). Does not detect extracellular FN (plasma FN). Cross-reacts with mouse, rat, monkey, pig, dog, cow and chicken fibronectin EDA (according to literature).

同种型:

Mouse IgG1

免疫原:

Recombinant Extra Domain A (EDA) region of human cellular fibronectin.

克隆号:

IST-9

偶联:

Preservative Free

产品浓度:

Lot dependent

保存温度:

+4°C