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折扣/货期| 货号：REV-31-1179-00-R100 | 规格：100 ul | 目录价：￥5726 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
anti-Phospho-AMPA Receptor (Ser845) (human), Rabbit Monoclonal (RM296)
别名:
Glutamate Receptor 1; GluR 1; GluA1; GluR-A; GluR-K1
产品描述:
AMPA receptors (AMPARs) are heterotetrameric complexes composed of subunits GluR1–4, each of them conferring specific properties on the active receptor, including trafficking motifs, which is related to synaptic plasticity. These glutamate receptors are responsible for the fast, immediate postsynaptic response to glutamate release. Therefore, the receptor–channel complex, predominantly permeable for sodium and potassium ions, activates fast and shows rapid desensitization. AMPA receptors are abundant and widely distributed in the central nervous system. GluR1 (Glutamate Receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter, L-glutamate, induces a conformation change that leads to the opening of the cation channel and converts the chemical signal to an electrical impulse. Then, the receptor desensitizes rapidly and enters a transiet inactive state characterized by the presence of a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8, GluR1 shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Phosphorylation of GluR1 is critical for long-term potentiation (LTP) and long-term depression (LTD) expression and the retention of memories.
宿主来源:
Rabbit
实验应用:
IHC, WB
靶标/特异性:
This antibody reacts to human Glutamate Receptor 1, AMPA Receptor (GluR1) only when phosphorylated at Ser845. There is no cross-reactivity to GluR1 that is not phosphorylated at Ser845. This antibody may also react to mouse or rat Phospho-AMPA Receptor (GluR1) (Ser845) as predicted by immunogen homology.
同种型:
Rabbit IgG
免疫原:
A phospho-peptide corresponding to human Phospho-Glutamate Receptor 1 (GluR1) (Ser845).
克隆号:
RM296
产品浓度:
N/A
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
产地:
瑞士
纯度:
Protein A purified.
上一个:anti-EGFR (human), Rabbit Monoclonal (RM294)
下一个:anti-CD79a (C-term) (human), Rabbit Monoclonal (RM297)
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