anti-RNASEH2B (human), Rabbit Monoclonal (RM433)-单抗-深圳欣博盛生物科技有限公司

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anti-RNASEH2B (human), Rabbit Monoclonal (RM433)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：REV-31-1321-00-R100

规格：100 ul

目录价：￥5726

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-RNASEH2B (human), Rabbit Monoclonal (RM433)

别名:

RNase H2 Subunit B; Ribonuclease H2 Subunit B; Aicardi-Goutieres Syndrome 2 Protein; AGS2; Deleted in Lymphocytic Leukemia 8

产品描述:

RNASE H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. RNASEH2B is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. It also mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2B are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). A form of hyper-inflammatory Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon and negative serologic investigations for common prenatal infection.

宿主来源:

Rabbit

实验应用:

IHC, WB

靶标/特异性:

RM433 reacts to human RNASEH2B.

同种型:

Rabbit IgG

免疫原:

A peptide corresponding to the C-terminus of human RNASEH2B.

克隆号:

RM433