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折扣/货期| 货号：37400-1 mg | 规格：1 mg | 目录价：￥590 |
| 货号：37400-10 mg | 规格：10 mg | 目录价：￥3524 |
| 货号：37400-25 mg | 规格：25 mg | 目录价：￥6606 |
| 货号：37400-5 mg | 规格：5 mg | 目录价：￥2198 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
AP1189 (acetate)
产品描述:
A biased MC1R and MC3R agonist; induces ERK1 and ERK2 phosphorylation but not canonical cAMP production in HEK293 cells expressing human MC1R or MC3R from 10 pM to 1 mM; reduces zymosan-induced IL-1β, IL-6, and TNF-α production in primary peritoneal macrophages isolated from wild-type but not Mc3r-/- mice from 0.1-10 nM; reduces zymosan-induced TNF-α production in primary macrophages isolated from Mc1r-/- mice; promotes efferocytosis in primary mouse macrophages; reduces peritoneal neutrophil infiltration in a mouse model of zymosan-induced acute peritonitis at 1, 3, and 10 mg/kg; reduces paw volume, the number of paws affected, and disease severity in a mouse model of arthritogenic serum-induced arthritis at 50 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
298.3002
产品形式:
A solid
纯度:
≥95%
CAS号:
959850-74-9
分子式:
C14H14N6O2 • C2H4O2
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