| 货号:37401-1 mg | 规格:1 mg | 目录价:¥389 |
| 货号:37401-10 mg | 规格:10 mg | 目录价:¥3390 |
| 货号:37401-25 mg | 规格:25 mg | 目录价:¥8000 |
| 货号:37401-5 mg | 规格:5 mg | 目录价:¥1809 |
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
产品名称:
Ezeprogind (sulfate)
产品描述:
An inhibitor of APP proteolysis; reduces the proteolysis of full-length APP to Aβ1-38 (IC50 = 5 µM) and Aβ1-40 (IC50 = 2 µM) in SH-SY5Y cells expressing APP; induces a doubling of AICD expression (C2 = 0.8 µM) without inducing cytotoxicity in wildtype SH-SY5Y cells (CC50 = 30 µM); inhibits Aβ1-42-induced cell death, dendritic network degradation, and loss of synapse integrity in primary rat cortical neurons at 10, 50, and 100 nM; decreases Aβ1-42 -induced Il-β and Il-6 secretion from, and the activation levels of, microglia in primary rat cortical neurons at 10, 50, and 100 nM; prevents and reverses the decline in spatial alternation retention in the Y-maze special alternation task in the SAMP8 mouse model of rapid aging and dementia at 3 mg/kg per day in drinking water for eight months and at the same dose for six and four months, respectively; decreases the number of hippocampal activated microglia in SAMP8 mice treated for eight and six months but not four months; reduces the proliferation of chloroquine-resistant P. falciparum (IC50 = 40.6 nM)
保存温度:
-20
运输温度:
-20
预期分子量:
428.6573
产品形式:
A solid
纯度:
≥98%
CAS号:
1616671-13-6
分子式:
C25H44N6 • 2H2SO4
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