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折扣/货期| 货号：29505-1 mg | 规格：1 mg | 目录价：￥509 |
| 货号：29505-10 mg | 规格：10 mg | 目录价：￥3672 |
| 货号：29505-5 mg | 规格：5 mg | 目录价：￥1970 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
AS-2444697 (hydrochloride)
产品描述:
An IRAK4 inhibitor (IC50 = 21 nM); greater than 30-fold selective for IRAK4 over a panel of 146 kinases, but is less than 10-fold selective over PDGFRα, PDGFRβ, TrkA, TrkC, CLK1, Itk, and FLT3; inhibits IL-1β-induced IL-6 production and LPS-induced TNF-α production in cellular assays (IC50s = 250 and 47 nM, respectively); efficacious in rat models of adjuvant- and collagen-induced arthritis (ED50s = 2.7 and 1.6 mg/kg, respectively); reduces urinary protein excretion, the development of interstitial fibrosis and glomerulosclerosis, and renal mRNA expression of genes encoding IL-1β, IL-6, TNF-α, and CCL2 in the 5/6 nephrectomized rat model of chronic kidney disease from 0.3-3 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
396.40014
产品形式:
A crystalline solid
纯度:
≥95%
CAS号:
1287665-60-4
分子式:
C19H20N6O4 • HCl
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