官网链接
折扣/货期| 货号：41841-1 mg | 规格：1 mg | 目录价：￥576 |
| 货号：41841-10 mg | 规格：10 mg | 目录价：￥3752 |
| 货号：41841-25 mg | 规格：25 mg | 目录价：￥7196 |
| 货号：41841-5 mg | 规格：5 mg | 目录价：￥2305 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ASP5878
产品描述:
An inhibitor of wild-type FGFR (IC50s = 0.47, 0.6, 0.74, and 3.5 nM for wild-type FGFR1, -2, -3, and -4, respectively) and mutant FGFR3K650E, FGFR3K560M, and FGFR4N535K (IC50s = 1.6, 4.2, and 78 nM, respectively); selective for these FGFRs over a panel of 128 additional kinases at 200 nM but does inhibit VEGFR2 and FMS (IC50s = 25 and 150 nM, respectively); selectively inhibits the proliferation of urothelial cancer cell lines with FGFR gene alterations (IC50s = FGFR gene alterations (IC50s = ≥300 nM); inhibits the proliferation of adriamycin-resistant UM-UC-14 cells and gemcitabine-resistant RT-112 cells (IC50s = 11 and 10 nM, respectively); induces tumor regression in a UM-UC-14 mouse xenograft model at 3 mg/kg; increases femur and tibia length and femur growth plate cartilage thickness in Fgfr3G380R male mice in a model of achondroplasia at 300 µg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
407.371566
产品形式:
A solid
纯度:
≥98%
CAS号:
1453208-66-6
分子式:
C18H19F2N5O4
促销活动
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