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折扣/货期| 货号：41842-1 mg | 规格：1 mg | 目录价：￥1461 |
| 货号：41842-10 mg | 规格：10 mg | 目录价：￥10224 |
| 货号：41842-25 mg | 规格：25 mg | 目录价：￥18251 |
| 货号：41842-5 mg | 规格：5 mg | 目录价：￥5842 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PF-06835919
别名:
Ketohexokinase Inhibitor 1
产品描述:
A KHK-C inhibitor (IC50 = 10 nM); selective for KHK-C over KHK-A (IC50 = 170 nM) and a panel of 89 kinases, phosphatases, and receptors at 10 µM; decreases the levels of fructose-1-phosphate in primary human- and rat hepatocytes (IC50s = 0.232 and 2.801 µM, respectively); inhibits glucose- and fructose-induced nuclear translocation of ChREBP in a reporter assay using primary rat hepatocytes at 30 µM; reduces the weight of epididymal adipose tissue, fasting plasma levels of insulin, liver levels of triglycerides, and fed- and fasting plasma levels of triglycerides and increases urinary levels of fructose in rats fed a high-fructose diet at 10 or 30 mg/kg twice per day; decreases plasma levels of ApoC3 and increases plasma levels of adiponectin in rats fed a Western diet at 20 or 60 mg/kg per day
保存温度:
-20
运输温度:
-20
预期分子量:
356.343029
产品形式:
A solid
纯度:
≥98%
CAS号:
2102501-84-6
分子式:
C16H19F3N4O2
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