AVPR2 antibody-多抗-深圳欣博盛生物科技有限公司

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AVPR2 antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX70835

规格：25μg

目录价：￥3800

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

AVPR2 antibody

别名:

arginine vasopressin receptor 2 , ADHR , AVPR2 , DI1 , DIR , DIR3 , NDI , V2R , AVP Receptor V2 , AVPR V2

反应种属:

Hamster, Human, Monkey, Mouse, Rabbit, Rat

宿主来源:

Rabbit

实验应用:

IHC-P

同种型:

IgG

免疫原:

Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human AVPR2.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by affinity chromatography

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, 0.1% Sodium azide.

生产商:

GeneTex

功能与背景:

This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]

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