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折扣/货期| 货号：26792-1 mg | 规格：1 mg | 目录价：￥549 |
| 货号：26792-10 mg | 规格：10 mg | 目录价：￥4181 |
| 货号：26792-25 mg | 规格：25 mg | 目录价：￥9112 |
| 货号：26792-5 mg | 规格：5 mg | 目录价：￥2385 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
B-RAF Inhibitor 1 (hydrochloride)
产品描述:
An inhibitor of Raf kinases (Kis = 0.3, 1, and 1 nM for C-RAF, B-RAF, and B-RAFV600E, respectively); selective for B-RAFV600E kinase domain over Lck, Tie2, KDR, and p38α (IC50s = 83, 120, 1,000, and >1,600 nM, respectively); inhibits phosphorylation of ERK in A375 melanoma cells (IC50 = 1.8 nM); reduces tumor growth in an A375 SQ2 mouse xenograft model (ED50 = 1.3 mg/kg per day) and induces 85% tumor regression at 5 mg/kg per day for 14 days; increases tumor growth in a MIA PaCa-2 mouse xenograft model at 5 and 10 mg/kg per day
保存温度:
-20
运输温度:
-20
预期分子量:
478.93568
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
1191385-19-9
分子式:
C26H19ClN8 • 2HCl
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