官网链接
折扣/货期| 货号：GTX101435 | 规格：100μl | 目录价：￥4000 |
| 货号：GTX101435-S | 规格：25μl | 目录价：￥1700 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
beta Catenin antibody [N1N2-2], N-term
别名:
catenin beta 1 , CTNNB , EVR7 , MRD19 , armadillo
产品描述:
Beta-catenin antibody recognizes beta-catenin protein, which acts as a cell adhesion factor as well as an effector of Wnt signaling pathway-driven transcription. Mutation or dysregulation of beta-catenin is associated with many diseases, including developmental disorders and cancers. There are a plethora of commercially available beta-catenin antibodies, among which GeneTex’s beta-catenin antibody (GTX101435) is one of the most rigorously validated and widely cited for a number of applications.
反应种属:
Cat, Dog, Human, Mouse, Rabbit, Rat, Zebrafish
宿主来源:
Rabbit
实验应用:
ChIP assay, FCM, ICC/IF, IHC, IHC-Fr, IHC-P, IHC-Wm, IP, WB
同种型:
IgG
免疫原:
Recombinant protein encompassing a sequence within the N-terminus region of human beta Catenin. The exact sequence is proprietary.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by antigen-affinity chromatography.
偶联:
Unconjugated
产品浓度:
0.13 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
85
产品形式:
Liquid
存储溶液:
PBS, 1% BSA, 20% Glycerol, 0.025% ProClin 300.
生产商:
GeneTex
功能与背景:
Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM]
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