BRAF V600E Antibody-单抗-深圳欣博盛生物科技有限公司

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BRAF V600E Antibody

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V5229-100UG	规格：100 ug	目录价：￥6652.1
货号：V5229-20UG	规格：20 ug	目录价：￥3082.1

产品详情

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产品名称:

BRAF V600E Antibody

产品描述:

The BRAF gene encodes a cytoplasmic serine-threonine kinase, which initiates the activation of the mitogen-activated protein kinase (MAPK) signalling pathway. The oncogenic mutations in the kinase region of BRAF gene result in constitutive activation of the MAPK signalling pathway, leading to increased cell proliferation, resistance to apoptosis and tumor progression. The most common of all activating BRAF mutations leads to a substitution of valine (V) to glutamic acid (E) at the position 600 of the amino acid sequence. The BRAF V600E mutation is an important predictive and prognostic biomarker. The BRAF V600E mutation is detected in approximately 8% of all solid tumours, including 45% of papillary thyroid carcinomas, 40-60% of melanomas, 5-15% of colorectal adenocarcinomas, 35% of serous low grade and borderline ovarian carcinomas, 1-3% of non-small cell lung cancers, and 5-7% of cholangiocarcinomas. Furthermore, the BRAF V600E mutation is found in 100% of hairy cell leukaemia, 54% Erdheim-Chester disease, 38% of Langerhans cell histocytoses and 60% of pleomorphic xanthoastrocytomas.

反应种属:

Human

宿主来源:

Mouse

实验应用:

ELISA

同种型:

Mouse IgG1, kappa

免疫原:

An N-terminal KLH-conjugated peptide (amino acids 596-606, Cys-GLAT(E)KSRWSG) was used as the immunogen for the BRAF V600E antibody.

克隆性:

Monoclonal (mouse origin)