官网链接
折扣/货期| 货号：V5544SAF-100UG | 规格：100 ug | 目录价：￥6652.1 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
BRCA1 Antibody / Breast Cancer Marker
产品描述:
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
反应种属:
Human
宿主来源:
Mouse
实验应用:
ELISA
同种型:
Mouse IgG2b, Lambda
免疫原:
A recombinant fragment (within amino acids 445-620) of human BRCA1 protein was used as the immunogen for the BRCA1 antibody.
克隆性:
Monoclonal (mouse origin)
克隆号:
BRCA1/2973
纯化方式:
Protein A/G affinity
保存温度:
Aliquot the BRCA1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
产品形式:
Purified
存储溶液:
1 mg/ml in 1X PBS; BSA free, sodium azide free
产地:
美国
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