BRCC36 Antibody-多抗-深圳欣博盛生物科技有限公司

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BRCC36 Antibody

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：4331-0.02 mg	规格：0.02 mg	目录价：￥1345.5
货号：4331-0.1 mg	规格：0.1 mg	目录价：￥6084

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

BRCC36 Antibody

别名:

BRCC36 Antibody: C6.1A, BRCC36, CXorf53, C6.1A, Lys-63-specific deubiquitinase BRCC36, BRCA1-A complex subunit BRCC36

反应种属:

Human,Mouse,Rat

宿主来源:

Rabbit

实验应用:

ELISA,WB,IHC-P,IF

同种型:

IgG

克隆性:

Polyclonal

纯化方式:

BRCC36 Antibody is affinity chromatography purified via peptide column.

偶联:

Unconjugated

产品浓度:

1 mg/mL

保存温度:

BRCC36 antibody can be stored at 4˚C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.

运输温度:

Blue Ice

产品形式:

Liquid

存储溶液:

BRCC36 Antibody is supplied in PBS containing 0.02% sodium azide.

产地:

美国

生产商:

Prosci

功能与背景:

BRCC36 Antibody: Together with the breast and ovarian predisposition proteins BRCA1 and BRCA2 and RAD51 and BRCC45, BRCC36 forms a holoenzyme complex that possesses a ubiquitin E3 ligase activity. Aberrant levels of BRCC36 were detected in sporadic breast tumors and depletion of either BRCC36 or BRCC45 by siRNA resulted in increased sensitivity to ionizing radiation and defects in the G2/M checkpoint, indicating that BRCC36 acts to enhance cellular survival following DNA damage. Recent experiments have shown that BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation, suggesting that BRCC36 may be an important target in the treatment of radiation-resistant breast tumors. At least two isoforms of BRCC36 are known to exist.

Accession #:

NP_077308

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