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折扣/货期| 货号：SPC-929D-A488 | 规格：100 µl | 目录价：￥4939.2 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
BubR1 Antibody (pSer670): ATTO 488
别名:
Beta homolg of S. cerevisiae BUB 1 antibody, Beta homolg of S. cerevisiae budding uninhibited by benzimidazoles antibody, BUB 1B antibody, BUB1 budding uninhibited by benzimidazoles 1 homolog beta antibody, Bub1A antibody, BUB1B antibody, BUB1B_HUMAN antibody, BUB1beta antibody, BUBR1 antibody, Budding Uninhibited by Benzimidazoles 1 beta antibody, Budding uninhibited by benzimidazoles 1 homolog beta (yeast) antibody, hBUBR1 antibody, MAD3/BUB1 related protein kinase antibody, MAD3L antibody, Mitotic checkpoint gene BUB1B antibody, Mitotic checkpoint kinase MAD3L antibody, MVA1 antibody, Protein SSK1 antibody, SSK 1 antibody, SSK1 antibody
产品描述:
Rabbit Anti-Human BubR1 (pSer670) Polyclonal
反应种属:
Human
宿主来源:
Rabbit
实验应用:
WB | AM
靶标/特异性:
Detects 119 kDa.
推荐稀释度:
WB (1:250); optimal dilutions for assays should be determined by the user.
免疫原:
A phospho-specific peptide corresponding to residues surrounding Ser670 of human BUBR1 (AA667-673)
免疫原种属:
Human
克隆性:
Polyclonal
纯化方式:
Peptide Affinity Purified
偶联:
ATTO 488
保存温度:
Conjugated antibodies should be stored according to the product label
运输温度:
Blue Ice or 4ºC
存储溶液:
PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
产地:
加拿大
功能与背景:
BUBR1 is a protein-serine/threonine kinase. It is an essential component of mitotic checkpoint. It prevents progression of anaphase until all the sister chomatids are connected to spindles by binding to CDC20 to anaphase promoting complex/cycolsome thus inhibiting it. It is also involved in localization of CENPE, a kinetochore motor that performs kinetochore functions. Other functions include suppression of centrosome amplification, negative regulation of PLK1 in intephase and trigger apoptosis in polyploid cells.
Accession #:
NP_001202
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