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折扣/货期| 货号：GTX14700 | 规格：50μl | 目录价：￥5000 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
c-Met antibody [3i20(25H2)]
别名:
AUTS9 , DFNB97 , HGFR , MET , MET protooncogene, receptor tyrosine kinase , RCCP2 , cMet , hepatocyte growth factor receptor , C-Met , MET proto-oncogene, receptor tyrosine kinase
反应种属:
Human, Macaque, Monkey, Mouse, Rat
宿主来源:
Mouse
实验应用:
IHC (Free Floating), IP, WB
靶标/特异性:
Recognizes endogenous levels of human Met at ~145kD and at 170kD for pro-Met.
同种型:
IgG1
免疫原:
Synthetic peptide corresponding to residues surrounding Tyr1234 of human Met.
克隆性:
Monoclonal
克隆号:
3i20(25H2)
纯化方式:
Unpurified
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
10mM Sodium HEPES, 150mM NaCl, 0.01% BSA, 50% Glycerol, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
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