c-Met antibody-多抗-深圳欣博盛生物科技有限公司

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c-Met antibody

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX10681

规格：25μg

目录价：￥4700

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

c-Met antibody

别名:

Met Proto-Oncogene , Ai838057 , Hgf , Hgfr , Par4 , C-Met , Met

反应种属:

Mouse

宿主来源:

Goat

实验应用:

ELISA, IHC, Neutralizing/Inhibition, WB

靶标/特异性:

Anti-Mouse Hepatocyte Growth Factor Receptor will neutralize receptor-ligand interaction. By ELISA, the antibody shows approximately 15% cross-reactivity with recombinant human HGF R and no cross-reactivity with recombinant human macrophage stimulating protein receptor (MSP R).

同种型:

IgG

免疫原:

Recombinant mouse hepatocyte growth factor receptor (HGF R) extracellulardomain expressed in Sf 21 cells.

克隆性:

Polyclonal

克隆号:

纯化方式:

Immunogen affinity purified

偶联:

Unconjugated

产品浓度:

0.1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, no preservatives.

生产商:

GeneTex

功能与背景:

Hepatocyte growth factor receptor (HGF R), a product of the proto-oncogene c-Met, is a heterodimeric transmembrane glycoprotein that is a receptor-type tyrosine kinase. The c-Met heterodimer is composed of an alpha chain that is disulfide-linked to a beta chain. Each alpha and beta subunit heterodimer contain 1152 amino acid residues with a calculated molecular mass of approximately 129 kDa. The alpha chain is exposed to the cell surface and the beta chain spans the plasma membrane. c-Met is synthesized as a single-chain precursor which undergoes cotranslational glycosylation and proteolytic cleavage producing the heterodimeric mature form. Human and mouse HGF receptors share 89% amino acid identity. HGF is the ligand for the HGF receptor. Human HGF can bind to the mouse HGF receptor.Hepatocyte growth factor (HGF), also known as scatter factor (SF), is a multifunctional cytokine that promotes mitogenesis, migration, invasion, and morphogenesis. HGF stimulates hepatocytes and other epithelial and endothelial cells by various biological actions. HGF binding involves the beta chain of the HGF receptor, but alpha chain participation cannot be ruled out. HGF binding to c-Met triggers dimerization and subsequent tyrosine autophosphorylation of the receptor beta chain. Autophophorylation at two tyrosines upregulates kinase activity while phosphorylation at two other tyrosines generates SH2 docking sites for adapter proteins such as Shc, Grb2, CrK/CRKL, and Gab1. Receptor activation has been correlated to the activation of the Ras pathway, which culminates in the activation and consequent nuclear translocation of MAP kinase. c-Met can also be negatively modulated by phosphorylation of Ser 985 by protein kinase C. Other ligand-receptor activities involve binding that leads to enhanced integrin-mediated B cell and lymphoma cell adhesion. Normal HGF-Met signaling is needed for embryonic development and abnormal signaling and has been implicated in tumorigenesis.

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