CCL21 antibody-多抗-深圳欣博盛生物科技有限公司

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CCL21 antibody

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX10364

规格：50μg

目录价：￥7100

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

CCL21 antibody

别名:

chemokine (C-C motif) ligand 21A (serine) , 6CKBAC2 , 6Ckine , ALP , AW987545 , CKb9 , SCYA21a , SLC , Scya21 , Scya21b , Tca4 , plt

反应种属:

Mouse

宿主来源:

Goat

实验应用:

ELISA, Neutralizing/Inhibition, WB

靶标/特异性:

The antibody has the ability to neutralize the biological activity of recombinant mouse 6Ckine. It exhibits less than 15% cross-reactivity with recombinant human 6Ckine.

同种型:

IgG

免疫原:

recombinant mouse 6Ckine, expressed in Escherichia coli.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by affinity chromatography

偶联:

Unconjugated

产品浓度:

Batch dependent (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

PBS, no preservatives.

生产商:

GeneTex

功能与背景:

Mouse 6Ckine is a beta- or C-C chemokine identified in the Expressed Sequence Tag (EST) database by three independent groups (Hedrick and Zlotnik, Hromas et al, Nagira et al). Known also as Exodus-2 and secondary lymphoid-tissue chemokine (SLC), 6Ckine contains four conserved cysteine (C) residues which are characteristic of beta-chemokines (Hedrick and Zlotnik, Hromas et al, Nagira et al). Two additional conserved cysteine residues have been found in its unusually long carboxy-terminal domain and consequently the name 6Ckine (Hedrick and Zlotnik, Hromas et al, Nagira et al). Human and mouse 6Ckine are highly conserved and show 86% amino acid homology.1 Mouse 6Ckine cDNA encodes a 133 amino acid precursor protein, a 23 amino acid signal peptide and a 110 amino acid mature protein. (Hedrick and Zlotnik). Comparatively, human 6Ckine cDNA encodes a 134 amino acid precursor protein, a 23 amino acid signal peptide and a 111 amino acid mature protein(Hedrick and Zlotnik, Nagira et al). Recombinant mouse 6Ckine has a predicted molecular mass of approximately 12 kDa (mature protein). In SDS-PAGE under reducing and non-reducing conditions, the recombinant protein migrates with an apparent molecular mass of 16 kDa to 17 kDA.The expression of mouse 6Ckine has been detected in high levels in the spleen and lung (Nagira et al). Recombinant mouse 6Ckine is chemotactic in vitro for thymocytes and activated T cells (Hedrick and Zlotnik). Unlike other C-C chemokines, 6Ckine is not chemotactic for monocytes and neutrophils (Hedrick and Zlotnik, Nagira et al). A growing body of work suggests that 6Ckine influences lymphocyte homing to secondary lymphoid organs (Gunn et al), integrin-mediated lymphocyte adhesion (Pachynski et al) and may act via the EBI1 ligand chemokine (ELC) receptor, CCR7 (Willimann et al, Yoshida et al).

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