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折扣/货期| 货号：AG-40B-0170-3010 | 规格：3 x 10 ug | 目录价：￥9600 |
| 货号：AG-40B-0170-C010 | 规格：10 ug | 目录价：￥4800 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
CD112R (mouse):Fc (human) (rec.)
别名:
CD112 Receptor; Poliovirus Receptor-related Immunoglobulin Domain-containing Protein; Transmembrane Protein PVRIG
产品描述:
CD112 (also called Nectin-2 or poliovirus receptor-related 2 protein) is a type I transmembrane glycoprotein and a member of the Ig gene superfamily (IGSF). CD112/Nectin-2 functions as an adhesion molecule involved in the formation of cell junctions and interactions with other Nectin-family molecules. Nectin-2 is a also a surface marker of some endothelial cells and regulates migration, proliferation and angiogenesis. CD112 functions as an immune checkpoint regulator by modulating T cell signaling, either as a costimulator of T cell function, or as a coinhibitor of T cells proliferation by binding to the receptors CD226 or TIGIT (T cell Ig and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain), respectively. The binding of CD112 ligand to these receptors is weak compared to CD155. Recently, a new receptor of CD112, called CD112R or PVRIG (Poliovirus receptor-related immunoglobulin domain-containing protein) has been characterized, showing high affinity to CD112. CD112R is a new coinhibitory receptor of the PVR family for human T cells, inhibiting TCR-mediated signals upon binding to CD112/Nectin-2. CD112R is preferentially expressed in T lymphocytes and NK cells. Cancer cells evade immune responses as a result of an immunosuppressive tumor microenvironment and CD112R, by playing a role in the regulation of the immune system, could be a new attractive cancer immunotherapy target.
宿主来源:
HEK 293 cells
产品浓度:
0.1mg/ml after reconstitution
保存温度:
+4°C
运输温度:
BI
预期分子量:
~48-50kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
产地:
瑞士
纯度:
>90% (SDS-PAGE)
生物活性:
Binds to the ligand mouse CD112 (PVRL2, Nectin-2) with an EC50 of 5nM.
内毒素水平:
<0.01EU/µg purified protein (LAL test).
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