CD152 [CTLA-4] (human) (rec.) (His)-其他重组蛋白-深圳欣博盛生物科技有限公司

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CD152 [CTLA-4] (human) (rec.) (His)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40B-0228-C050

规格：50 ug

目录价：￥2400

产品详情

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产品名称:

CD152 [CTLA-4] (human) (rec.) (His)

别名:

Cytotoxic T-lymphocyte-associated Antigen 4; Cytotoxic T-lymphocyte Protein 4

产品描述:

CD152 (Cytotoxic T-lymphocyte-associated protein 4; CTLA-4) is an inhibitory receptor belonging to the CD28 immunoglobulin subfamily, expressed primarily by T-cells. Its ligands, CD80 and CD86, are typically found on the surface of antigen-presenting cells and can either bind CD28 or CTLA-4, resulting in a costimulatory or a co-inhibitory response, respectively. Because of its dampening effect, CTLA-4 is a crucial regulator of T-cell homeostasis and self-tolerance. While CD28 promotes T-cell activation and proliferation, CTLA-4 is reported to dampen T-cell responses through a variety of mechanisms. Prior to activation, conventional T-cells (Tconv) express low levels of CTLA-4, predominantly in intracellular compartments. Upon activation, CTLA-4 expression is upregulated and becomes increasingly detectable on the cell surface. In Tregs on the other hand, transmembrane CTLA-4 is constitutively expressed and plays an important role in Treg homeostasis and function. In general, T-cell CTLA-4 is largely constrained to intracellular expression although some surface expression may be detectable owing to the rapid, continuous shuttling of CTLA-4 between intracellular compartments and the plasma membrane. Recently, roles of CTLA-4 have been demonstrated in dendritic cells and tumors, showing that CTLA-4 plays nonredundant and critical roles in thymic development, T-cell priming, peripheral tolerance, and a variety of other critical immunoregulatory functions as an immune checkpoint in Immuno-oncology research.

宿主来源:

HEK 293 cells

产品浓度:

1mg/ml after reconstitution.

保存温度:

+4°C

运输温度:

预期分子量:

~20kDa (SDS-PAGE)

产品形式:

solid

存储溶液: