Human Recombinant Alpha Synuclein E83Q Mutant PFFs-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human Recombinant Alpha Synuclein E83Q Mutant PFFs

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-539E

规格：100 µg x5

目录价：￥23751

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Human Recombinant Alpha Synuclein E83Q Mutant PFFs

别名:

Alpha Synuclein E83Q, Alpha-Synuclein E83Q, α synuclein E83Q, E83Q synuclein, Alpha Synuclein E83Q mutant, SNCA E83Q mutation, Alpha Synuclein NAC mutation E83Q, SNCA E83Q Aggregated Protein, Seeding‑Competent Alpha‑Synuclein E83Q Fibrils

实验应用:

In vitro Assay | In vivo Assay

纯化方式:

Ion-exchange Purified

偶联:

No Tag

产品浓度:

2 mg/ml

表达系统:

E. coli

保存温度:

-80ºC

运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

预期分子量:

14.46 kDa

存储溶液:

PBS pH 7.4

产地:

加拿大

生产商:

Stressmarq

功能与背景:

Alpha Synuclein E83Q is a rare missense variant of the SNCA gene, in which glutamate is replaced by glutamine at residue 83 within the non-amyloid-β component (NAC) region, a sequence central to alpha-synuclein aggregation and fibril formation. E83Q was initially identified in a patient presenting with parkinsonism, progressive non-amnestic dementia, severe frontotemporal atrophy, and extensive cortical Lewy body pathology in the absence of tau or TDP-43 pathology. Subsequent biochemical, structural, cellular, and neuronal studies demonstrated that E83Q markedly accelerates alpha-synuclein fibrillization, produces fibrils with altered structural and dynamic properties, and is associated with increased alpha-synuclein accumulation, Ser129 phosphorylation, cellular toxicity, neuronal fibril uptake, and seeding activity relative to wild-type alpha-synuclein. StressMarq’s Human Recombinant Alpha Synuclein E83Q Mutant Monomers have been demonstrated to self-aggregate readily and form pre-formed fibrils (PFFs) that exhibit reduced Thioflavin T (ThT) binding relative to PFFs formed by wild-type alpha synuclein.

纯度:

> 95%

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