CD40L (human) ELISA Kit-人ELISA试剂盒-深圳欣博盛生物科技有限公司

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CD40L (human) ELISA Kit

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-45B-0018-KI01

规格：96 wells

目录价：￥7320

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

CD40L (human) ELISA Kit

别名:

CD40 Ligand; CD154; Tumor Necrosis Factor Ligand Superfamily Member 5; TNFSF5; Gp39; TRAP

产品描述:

CD40 (also called, Tumor necrosis factor receptor superfamily member 5 or TNFRSF5), a transmembrane type I glycoprotein, belongs to the tumor necrosis factor (TNF) gene superfamily and behaves as a co-stimulatory molecule found on B cells, monocytes, antigen presenting cells, endothelial, smooth muscle cells, fibroblasts and platelets. Its ligand, CD40L (also called CD154), a type II transmembrane protein, is a 261 amino acid (aa) glycoprotein that forms homotrimers. CD40L is found on activated T cells, B cells, platelets, endothelial, epithelial and smooth muscle cells. Proteolytic cleavage can produce a soluble form of CD40L (sCD40L). Platelets are the main source of sCD40L. CD40-CD40L interaction is an essential signal for B cell proliferation, expression of activation markers, immunoglobulin production and isotype switching, formation of B memory cells and germinal centers. It also prevents apoptosis of germinal center B cells. Defective expression of CD40L in humans leads to an inability to produce isotypes other than IgM (hyper IgM syndrome) and to an absence of germinal centers. In dendritic cells, CD40 ligation induces more effective antigen, enhances T-cell stimulatory capacity and induces production of several inflammatory cytokines and chemokines. CD40-CD40L interactions are crucially involved in development of autoimmune disease and have also impact on growth regulation of certain carcinomas. Elevated levels of sCD40L have been observed in sera from patients with systemic lupus erythematosus (SLE), chronic lymphocytic leukemia (CLL) and unstable angina.

靶标/特异性:

Detects soluble human CD40L in serum, plasma and cell culture supernatant.

保存温度:

+4°C

运输温度:

产地:

瑞士

灵敏度:

20pg/ml

检测范围:

0.03125 to 2ng/ml

检测方法: