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折扣/货期| 货号：AG-40B-0010CSG-C100 | 规格：100 ug | 目录价：￥19200 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
CD40L (human) (multimeric) (rec.) (Certified Serum Grade)
别名:
MultimericCD40L™; ACRP30headless:CD40L; ACRP30headless:CD154; ACRP30headless:TNFSF5; ADIPOQ-CD40L
产品描述:
MultimericCD40L™ is a high-activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to [CD40L+enhancer] combinations. MultimericCD40L™ has been shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time-dependent manner, without affecting BMDM viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced. MultimericCD40L™ has been shown to be a potent tool for B cell expansion. It also has big potential as a growth factor for tumor-infiltrating lymphocytes (TILs), which have been shown to be important for T cell therapy.
宿主来源:
CHO cells. Produced using certified serum/medium.*
靶标/特异性:
Binds to human CD40.
产品浓度:
1mg/ml
保存温度:
-20°C
运输温度:
DI
预期分子量:
~35-40kDa (SDS-PAGE)
产品形式:
liquid
存储溶液:
Liquid. Contains PBS.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86) (ED50: <1ng/ml). B cell expansion online protocol available.
内毒素水平:
<0.01EU/µg purified protein (LAL test, Lonza).
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