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折扣/货期| 货号：GTX83198 | 规格：100μl | 目录价：￥6100 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Chk2 antibody [1C12B8]
别名:
checkpoint kinase 2 , CDS1 , CHK2 , HuCds1 , LFS2 , PP1425 , RAD53 , hCds1
反应种属:
Human
宿主来源:
Mouse
实验应用:
ELISA, ICC/IF, IHC-P, WB
同种型:
IgG2b
免疫原:
Purified recombinant fragment of human CHK2 (aa481-531) expressed in E. Coli.
克隆性:
Monoclonal
克隆号:
1C12B8
纯化方式:
Unpurified
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
61
产品形式:
Liquid
存储溶液:
Ascites, 0.03% Sodium azide.
生产商:
GeneTex
功能与背景:
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarc
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