EDA-A1, Soluble Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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EDA-A1, Soluble Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：90-288

规格：10 ug

目录价：￥5756.4

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

EDA-A1, Soluble Recombinant Protein

别名:

Ectodysplasin-A, Ectodermal Dysplasia Protein

产品浓度:

0.1mg/ml after reconstitution.

表达系统:

E. coli

保存温度:

Stable for at least 6 months after receipt when stored at -20˚C.

运输温度:

Blue Ice

产品形式:

Lyophilized

存储溶液:

Contains PBS. Reconstitute with 100 μl sterile water.

产地:

美国

生产商:

Prosci

功能与背景:

The TNF family ligand ectodysplasin A (EDA) and its receptor EDAR are required for proper development of skin appendages such as hair, teeth, and eccrine sweat glands. Loss of function mutations in the Eda gene cause X-linked hypohidrotic ectodermal dysplasia (XLHED), a condition that can be ameliorated in mice and dogs by timely administration of recombinant EDA. The Eda gene on the X chromosome is transcribed as multiple splice variants, only two of which code for the receptor-binding C-terminal TNF homology domain. These two variants code for 391- and 389-amino acid-long proteins called EDA1 and EDA2. EDA1 binds EDAR, whereas EDA2 binds to another receptor, XEDAR. The biology of EDA2 and XEDAR is distinct from that of EDA1. Indeed, XEDAR-deficient mice have no obvious ectodermal dysplasia phenotype, whereas mice deficient in EDA, EDAR, or the signaling adaptor protein EDARADD all display virtually indistinguishable ectodermal dysplasia phenotypes, indicating the predominance of the EDA1-EDAR axis in the development of skin-derived appendages.

纯度:

>95% (SDS-PAGE).

Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).

Accession #:

Q92838

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