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折扣/货期| 货号：GTX89185-PEP | 规格：100μg | 目录价：￥3200 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
CNTFR alpha blocking peptide
别名:
spindle and kinetochore associated complex subunit 3 , C13orf3 , RAMA1
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
ELISA, WB
同种型:
IgG
免疫原:
SKA3 antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human SKA3.The immunogen is located within amino acids 290 - 340 of SKA3.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by antigen-affinity chromatography
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
运输温度:
4°C
预期分子量:
46
产品形式:
Liquid
存储溶液:
PBS, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
Upon entry into mitosis, the cell’s microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Like with SKA1 or SKA2, depletion of SKA3 by siRNA delays anaphase transition, resulting in a prolonged a metaphase-like state. These SKA3-depleted cells accumulate high levels of the checkpoint protein Bub1 at kinetochores, suggesting the SKA complex plays a key role in spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis.
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