Cochlin (human) (LCCL domain) (rec.)-其他重组蛋白-深圳欣博盛生物科技有限公司

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Cochlin (human) (LCCL domain) (rec.)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40B-0135-3010	规格：3 x 10 ug	目录价：￥7200
货号：AG-40B-0135-C010	规格：10 ug	目录价：￥3600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Cochlin (human) (LCCL domain) (rec.)

别名:

COCH-5B2 (LCCL domain)

产品描述:

Cochlin is an extracellular matrix protein expressed in the cochlea and vestibule of the inner ear. Mutations in the cochlin gene are linked to the autosomal-dominant DFNA9 syndrome, a disorder characterized by hearing loss. Cochlin is also expressed in follicular dendritic cells of the spleen and the lymph nodes. The N-terminus of cochlin contains a LCCL domain also present in Factor C, a serine protease of the horseshoe crab Limulus, involved in activating the coagulation cascade in response to LPS. A recent study showed that in response to inflammation, LPS or bacterial infection, cochlin is cleaved by the proteases aggrecanases and secreted into blood circulation. The secreted cochlin (LCCL domain) seems to have a role in local cytokine production, recruitment of immune effector cells and bacterial clearance. Cochlin is secreted as two forms p8 and p18, whereas p18 being the glycosylated form of p8.

宿主来源:

HEK 293 cells

产品浓度:

0.1mg/ml after reconstitution

保存温度:

+4°C

运输温度:

预期分子量:

~8kDa and 18kDa

产品形式:

solid

存储溶液: