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折扣/货期| 货号：GTX54399 | 规格：50μg | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Collagen II antibody [M2139]
别名:
collagen, type II, alpha 1 , Col2 , Col2a , Col2a-1 , Del1 , Dmm , Lpk , M100413 , Rgsc413 , Rgsc856
反应种属:
Bovine, Chicken, Human, Mouse, Rat
宿主来源:
Mouse
实验应用:
ELISA, ICC/IF, IHC-Fr, IHC-P, Neutralizing /Inhibition, WB
靶标/特异性:
The monoclonal antibody M2139 reacts with the J1 epitope (triple helical position 551-564) of collagen type II. Collagen is a structural protein in bone, cartillage and connective tissue. The monocolonal antibody M2139 has been shown to induce CAIA in naïve mice after injection of lipopolysacharide (LPS). However, in combination with the monoclonal antibody CIIC1, binding to the C1 epitope of CII, the pair of monoclonal antibodies induce arthritis in different strains of mice without any other stimulants. The presence of secondary stimulus, LPS, increases the disease incidence and severity.
同种型:
IgG2b
免疫原:
The immunogen corresponding to a region within amino acids 551 and 564 of mouse Collagen II.
克隆性:
Monoclonal
克隆号:
M2139
纯化方式:
Protein G purified
偶联:
Unconjugated
产品浓度:
100 μg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
Filter-sterilized PBS, 0.1% BSA, no preservatives.
生产商:
GeneTex
功能与背景:
This gene encodes the alpha-1 subunit of the fibril-forming type II collagen, the major component of cartilage and the vitreous humor of the eye. The encoded preproprotein forms homotrimeric, triple helical procollagen that undergoes proteolytic processing during fibirl formation. Mice harboring certain mutations in this gene exhibit severe chondrodysplasia characterized by short limbs and trunch, craniofacial deformities and cleft palate. A complete lack of the encoded protein in mice results in postnatal lethality. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Dec 2015]
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