COT Antibody-多抗-深圳欣博盛生物科技有限公司

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COT Antibody

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：63-284

规格：400 ul

目录价：￥8687.25

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

COT Antibody

别名:

Mitogen-activated protein kinase kinase kinase 8, Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2, TPL-2, MAP3K8, COT, ESTF

反应种属:

Human

宿主来源:

Rabbit

实验应用:

WB,IHC-P

同种型:

Rabbit Ig

克隆性:

Polyclonal

纯化方式:

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

偶联:

Unconjugated

产品浓度:

batch dependent

保存温度:

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

运输温度:

Blue Ice

产品形式:

Liquid

存储溶液:

Supplied in PBS with 0.09% (W/V) sodium azide.

产地:

美国

生产商:

Prosci

功能与背景:

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK8 is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. The protein appears to play an important role in the cell cycle. This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines. The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle. The longer form undergoes phosphorylation on Ser residues mainly, and the shorter form on both Ser and Thr residues.

Accession #:

P41279

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