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折扣/货期| 货号：19-026 | 规格：100 uL | 目录价：￥7651.8 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
CXCR2 Antibody
别名:
Cxcr2, mIL-8RH, interleukin-8 receptor type B, interleukin 8 receptor, beta, IL-8Rh, IL-8rb, Il8rb, IL8RA, IL-8R B, IL-8 receptor alpha chain, high affinity interleukin-8 receptor B, GRO/MGSA receptor, Gpcr16, CXC-R2, CXCR-2, C-X-C chemokine receptor type 2, Cmkar2, chemokine (C-X-C) receptor 2, chemokine (C-X-C motif) receptor 2, CDw128, CD128, IL8RB
反应种属:
Human,Mouse,Rat
宿主来源:
Rabbit
实验应用:
WB
同种型:
IgG
克隆性:
Polyclonal
纯化方式:
Affinity purification
偶联:
Unconjugated
产品浓度:
batch dependent
保存温度:
Store at -20˚C. Avoid freeze / thaw cycles.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
产地:
美国
生产商:
Prosci
功能与背景:
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
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