官网链接
折扣/货期| 货号：41982-1 mg | 规格：1 mg | 目录价：￥1166 |
| 货号：41982-10 mg | 规格：10 mg | 目录价：￥6995 |
| 货号：41982-25 mg | 规格：25 mg | 目录价：￥13105 |
| 货号：41982-5 mg | 规格：5 mg | 目录价：￥4368 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Daraxonrasib
别名:
RMC-6236
产品描述:
A non-covalent inhibitor of GTP-bound Ras; binds to PPIase A (Kd = 55.3 nM) to form a binary complex that then binds to wild-type K-Ras, K-Ras(G12V), and K-Ras(G12D) (Kds = 131, 364, and 154 nM, respectively); forms a trimeric complex with PPIAse A and a K-Ras, H-Ras, N-Ras, or mutant Ras variant and disrupts the protein-protein interaction between these Ras variants and the B-RAF Ras-binding domain (IC50s = 28-220 nM); induces apoptosis in 28 K-Ras(G12X) and five N-Ras(Q61X) mutant cancer cell lines from 1-100 nM; inhibits intratumoral ERK phosphorylation and reduces tumor volume in Capan-2 and NCI H441 PDAC mouse 1xenograft models at 25 mg/kg; reduces tumor growth in 29 NSCLC, 22 PDAC, and 23 colorectal cancer K-Ras(G12X) mutant mouse xenograft models at 25 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
811.1
产品形式:
A solid
纯度:
≥98%
CAS号:
2765081-21-6
分子式:
C44H58N8O5S
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