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折扣/货期| 货号：V5241-100UG | 规格：100 ug | 目录价：￥6652.1 |
| 货号：V5241-20UG | 规格：20 ug | 目录价：￥3082.1 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
DBC1 Antibody / Deleted in breast cancer gene 1 / CCAR2
产品描述:
DBC-1 (deleted in breast cancer gene 1 protein), also known as p30 DBC protein and Cell cycle and apoptosis regulator protein 2 (CCAR2), is one of the genes located within the region of chromosome 8p21.3 that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal, an N-terminal leucine zipper, an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNF-Alpha, endogenous DBC-1 undergoes caspase-dependent processing to generate DBC-1 p120 and p66, both of which include the C-terminus of the protein. Both DBC-1 p120 and p66 relocate to the cytoplasm. Overexpression of the DBC-1 p120 form results in mitochondrial clustering and matrix condensation and increases the sensitivity of cells to TNF-Alpha-mediated apoptosis. In addition, DBC-1 directly interacts with unliganded ER-Alpha, stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth.
反应种属:
Human
宿主来源:
Mouse
实验应用:
FACS, IHC-P
同种型:
Mouse IgG2a
免疫原:
Recombinant full-length human CCAR2 / KIAA1967 protein was used as the immunogen for the DBC1 antibody.
克隆性:
Monoclonal (mouse origin)
克隆号:
PCRP-KIAA1967-1D10
纯化方式:
Protein A/G affinity
保存温度:
Aliquot the DBC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
产品形式:
Purified
存储溶液:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
产地:
美国
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