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折扣/货期| 货号：GTX26096 | 规格：50μg | 目录价：￥2400 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
DcR1 peptide
别名:
Tnf Receptor Superfamily Member 10C , Cd263 , Dcr1 , Dcr1-Tnfr , Lit , Trail-R3 , Trailr3 , Trid , Tnfrsf10C
实验应用:
Neutralizing/Inhibition
克隆号:
偶联:
Unconjugated
产品浓度:
0.20 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store the peptide at -20ºC, stable for one year.
运输温度:
dry ice
产品形式:
Liquid
存储溶液:
PBS, 0.1% BSA, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.
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