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折扣/货期| 货号：63-405 | 规格：400 ul | 目录价：￥8687.25 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
DGKQ Antibody
别名:
Diacylglycerol kinase theta, DAG kinase theta, Diglyceride kinase theta, DGK-theta, DGKQ, DAGK4
反应种属:
Human
宿主来源:
Rabbit
实验应用:
WB,IHC-P,Flow
同种型:
Rabbit Ig
克隆性:
Polyclonal
纯化方式:
This antibody is purified through a protein A column, followed by peptide affinity purification.
偶联:
Unconjugated
产品浓度:
batch dependent
保存温度:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
Supplied in PBS with 0.09% (W/V) sodium azide.
产地:
美国
生产商:
Prosci
功能与背景:
Diacylglycerol (DAG) is an allosteric activator of protein kinase C. DAG also participates in regulating RAS and RHO family proteins by activating the guanine nucleotide exchange factors VAV and RASGRP1. DAG is also involved in the synthesis of phospholipids and triacylglycerols. Tight regulation of DAG levels is achieved via DAG kinases (DGKs), which remove DAG by phosphorylate it to phosphatidic acid.The predicted 882-amino acid human DGKQ (DGK-theta) protein is 90% identical in sequence to the rat homolog. DGK-theta is comprised of a pleckstrin homology domain and the conserved DGK putative catalytic domain. In contrast to other DGK isotypes, DGK-theta contains 3 rather than 2 cysteine-rich zinc-binding domains, an N-terminal proline- and glycine-rich region, and a RAS-associating domain. Highest tissue expression in the rat is in the brain. Defects in eye-specific DAGK genes cause retinal degeneration in Drosophila; thus, DAGK genes are candidates for human eye disease.
Accession #:
P52824
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