DMB [GLP-1R Agonist]-激动剂-深圳欣博盛生物科技有限公司

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DMB [GLP-1R Agonist]

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CR1-3759-M001	规格：1 mg	目录价：￥540
货号：AG-CR1-3759-M005	规格：5 mg	目录价：￥2160
货号：AG-CR1-3759-M025	规格：25 mg	目录价：￥6480

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

DMB [GLP-1R Agonist]

别名:

GSDMD Activator; 6,7-Dichloro-N-(1,1-dimethylethyl)-3-(methyl-sulfonyl)-2-quinoxalinamine; 6,7-Dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline (DMB)

产品描述:

DMB is a small molecule GLP-1 receptor agonist (GLP-1R; KB = 26.3 nM for the recombinant human receptor). DMB exerts its activating effect by forming hydrogen bonds with the Tyr42, Cys71 and Ser84 residues of GLP-1R. GLP-1 receptor signaling is a predominant mechanism for regulating glucose homeostasis. DMB represents a unique non-peptide tool for studying the role of GLP-1 in both in vivo and in vitro diabetes and obesity models. DMB is a selective small molecule gasdermin D (GSDMD) agonist for inducing pyroptosis and enhancing anti-tumor immunity. DMB can directly activate GSDMD-mediated cancer cell pyroptosis. Unlike traditional pathways requiring GSDMD cleavage, DMB induces pyroptosis without this step, effectively stimulating anti-tumor immune responses with minimal toxicity. It achieves this by covalently modifying the Cys191 residue in GSDMD, disrupting the interaction between the N-terminus (NT) and C-terminus (CT). This keeps GSDMD in an activated state without cleavage, promoting pore formation and inducing pyroptosis while preserving the overall GSDMD structure.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

348.2

产品形式:

solid

产地:

瑞士

纯度:

>98% (HPLC)