DNA/RNA Damage Antibody: FITC-单抗-深圳欣博盛生物科技有限公司

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DNA/RNA Damage Antibody: FITC

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SMC-155D-FITC

规格：100 µg

目录价：￥4498.2

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

DNA/RNA Damage Antibody: FITC

别名:

8-Hydroxy Guanine Antibody, 8-OH-dG Antibody, 8OHG Antibody, 80G Antibody, 8 hydroxyguanine Antibody, 8 hydroxy 2' deoxyguanosine Antibody, 8 hydroxyguanosine Antibody, 8 OHG Antibody, 8-OHG Antibody, 8OHdG Antibody

产品描述:

Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

反应种属:

Species Independent

宿主来源:

Mouse

实验应用:

IHC | ICC/IF | ELISA | DB | IP | FCM | FA

靶标/特异性:

Recognizes markers of oxidative damage to DNA (8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanine and 8-hydroxyguanosine).

同种型:

IgG2b

推荐稀释度:

IHC (1:1000); optimal dilutions for assays should be determined by the user.

免疫原:

8-hydroxy-guanosine-BSA and –casein conjugates

克隆性:

Monoclonal

克隆号:

15A3

纯化方式:

Protein G Purified

偶联:

FITC

产品浓度:

1 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may be subject to change

产地:

加拿大

功能与背景:

DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are oxidation, alkylation, hydrolysis and mismatch of the bases. During the oxidation of bases, highly reactive chemical entities collectively known as RONS, occurs. RONS stands for reactive oxygen and nitrogen species and includes nitric oxide, superoxide, hydroxyl radical, hydrogen peroxide and peroxynitrite. Numerous studies have shown that RONS causes a variety of issues including DNA damage(1). 8-hydroxyguanine, 8-hydroxy-2'-deoxyguanonsine and 8- hydroxyguanosine are all RNA and DNA markers of oxidative damage. 8-hydroxy-2'-guanosine is produced by reactive oxygen and nitrogen species including hydroxyl radical and peroxynitrite. Specifically its high biological relevance is due to its ability to induce G to T transversions, which is one of the most frequent somatic mutations (2). 8-hydroxy-guanine has been the most frequently studied type of DNA base damage, with studies in diabetes, and cancer. Base modifications of this type arise from radical-induced hydroxylation and cleavage reactions of the purine ring (3, 4). And finally, 8-hydroxy-guanosine, like 8-hydroxy-2'-guanosine, induces a mutagenic transversion of G to T in DNA. Its role has specifically been tested in the development of diabetes, hypertension and strokes (5, 6, and 7).