DNMT1 Antibody: ATTO 488-单抗-深圳欣博盛生物科技有限公司

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DNMT1 Antibody: ATTO 488

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SMC-200D-A488

规格：100 µg

目录价：￥4926.6

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

DNMT1 Antibody: ATTO 488

别名:

DNA Mtase Antibody, DNMT Antibody, MCMT Antibody, DNA methyltransferase 1 Antibody, AIM Antibody, CXXC9 Antibody, DNMT Antibody, DNA (cytosine-5)-methyltransferase 1 Antibody, CXXC-type zinc finger protein 9 Antibody, DNA methyltransferase HsaI Antibody

产品描述:

Mouse Anti-Human DNMT1 Monoclonal IgG1 Kappa

反应种属:

Human | Mouse | Fish | Zebrafish (Danio rerio)

宿主来源:

Mouse

实验应用:

WB | IHC | IP | ChIP

靶标/特异性:

Detects ~180kDa. It will cross-react with mouse DNMT1.

同种型:

IgG1 Kappa

推荐稀释度:

WB (1:1000), IHC (1:1000); optimal dilutions for assays should be determined by the user.

免疫原:

Raised against a synthetic peptide corresponding to amino acids 637-650 of human DNMT1

免疫原种属:

Human

克隆性:

Monoclonal

克隆号:

60B1220.1

纯化方式:

Protein G Purified

偶联:

ATTO 488

产品浓度:

1 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Dnmt1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1. Dnmt1 also cooperates with Rb to repress transcription from promoters containing E2F-binding sites suggesting a link between DNA methylation, histone deacetylase and sequence-specific DNA binding activity, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells (1-6).

Accession #:

NP_001370