DOK2 Antibody-多抗-深圳欣博盛生物科技有限公司

首页产品中心多抗

DOK2 Antibody

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：63-148

规格：400 ul

目录价：￥8687.25

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

DOK2 Antibody

别名:

Docking protein 2, Downstream of tyrosine kinase 2, p56(dok-2), DOK2

反应种属:

Human

宿主来源:

Rabbit

实验应用:

WB,IHC-P

同种型:

Rabbit Ig

克隆性:

Polyclonal

纯化方式:

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

偶联:

Unconjugated

产品浓度:

batch dependent

保存温度:

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

运输温度:

Blue Ice

产品形式:

Liquid

存储溶液:

Supplied in PBS with 0.09% (W/V) sodium azide.

产地:

美国

生产商:

Prosci

功能与背景:

Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. Dok-2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. Dok-2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the Dok1 and Dok2 proteins and their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras and that the Dok proteins serve as mediators of bcr-abl signaling. The role of Dok proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia (CML), which is characterized by a Philadelphia chromosome translocation t(9;22). Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.

Accession #:

O60496

您可能感兴趣的产品

sPLA2 (human Type IIA) Polyclonal Antibody - Purified IgG

货号：45805

PAD3 Polyclonal Antibody

货号：33913

Growth Hormone (rat) Polyclonal Antibody for IHC

货号：C03904.25 µl

Goat Anti-ImmunoglobulinG (mouse) Polyclonal Antibody

货号：C03757.10 ml

Goat Anti-ImmunoglobulinG (rat) Polyclonal Antibody