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折扣/货期| 货号：99-188 | 规格：0.1 mg | 目录价：￥8125.65 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
DR5 Antibody
反应种属:
Human
宿主来源:
Rabbit
实验应用:
IHC-Fr,ICC,Flow,Blocking,IP
靶标/特异性:
DR5
同种型:
IgG
克隆性:
Polyclonal
偶联:
Unconjugated
产品浓度:
0.5 mg/mL
保存温度:
Store vial at 2-8˚C
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
产地:
美国
生产商:
Prosci
功能与背景:
DR5, also known as TRAIL-R2, TRICK2 and KILLER, is a widely expressed type I membrane member of the tumor necrosis (TNF) receptor family. Members of this family contain multiple cysteine-rich repeats in their extracellular domain and while the cytoplasmic region is less conserved, they do contain an intracellular 80 amino acid motif known as the ‘death domain’ (DD). DR5 is a receptor for the cytotoxic ligand TRAIL which induces apoptosis and it is the cytoplasmic DD that is responsible for transducing the death process. DR5 has also been shown to activate NF-κB.
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