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折扣/货期| 货号：GTX11512 | 规格：100μl | 目录价：￥7900 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
E-Cadherin antibody [DECMA-1]
别名:
cadherin 1 , AA960649 , ARC-1 , E-cad , Ecad , L-CAM , UVO , Um
反应种属:
Bovine, Dog, Human, Mouse
宿主来源:
Rat
实验应用:
ICC/IF, IHC-Fr, IHC-P, IP, WB
靶标/特异性:
Monoclonal Anti-Uvomorulin/E-Cadherin was selected against the mouse cell adhesion molecule uvomorulin/E-Cadherin. The antibody localizes the cell surface glycoprotein uvomorulin/E-cadherin that has been found to be identical to L-CAM, Cell CAM 80/120, and ARC-1. It blocks both the aggregation of mouse embryonal carcinoma cells and the compaction of pre-implantation embryos. The antibody disrupts confluent monolayers of Madin-Darby canine kidney (MDCK) epithelial cells. In indirect immunofluorescent staining of MDCK cells grown in culture, the antibody shows strong staining on the membrane of adjacent cells, after treatment with 0.5% Triton-X 100.
同种型:
IgG1
免疫原:
mouse embryonal carcinoma cell line PCC4 Aza R1.
克隆性:
Monoclonal
克隆号:
DECMA-1
纯化方式:
Unpurified
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
Ascites, 15mM Sodium azide.
生产商:
GeneTex
功能与背景:
Cell-cell interactions during embryonic development and in tissue organization involve specific cell-adhesion molecules (CAMs) that are functionally defined by antibodies that interfere with cell-cell adhesion. CAMs are expressed on early embryonic cells and persist in derivatives of all three germ layers. The best characterized CAMs are N-CAM (neural CAM) and L-CAM (liver CAM). The protein Uvomorulin, initially identified in embryonal carcinoma, is identical to L-CAM, E-Cadherin, Cell CAM 80/120 and ARC-1, each of which have been characterized in different systems. E-Cadherin has been characterized as a 120 kDa cell surface glycoprotein from which an 84 kDa fragment can be released by trypsin digestion in the presence of Ca2+.
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