EBI3 Antibody / Epstein-Barr virus induced 3-抗病毒抗体-深圳欣博盛生物科技有限公司

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EBI3 Antibody / Epstein-Barr virus induced 3

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V5599SAF-100UG

规格：100 ug

目录价：￥6652.1

产品详情

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产品名称:

EBI3 Antibody / Epstein-Barr virus induced 3

产品描述:

Epstein-Barr virus-induced gene 3 (Ebi3) is a widely expressed homolog to the interleukin IL-12 p40 subunit protein that forms a heterodimer with either IL-12 p35 or an IL-12 p35 homolog, p28, to create a new cytokine (IL-27). IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4+ T cells. Interferon-b differentially regulates expression of the IL-12 family members p35, p40, p19 and Ebi3 in activated human dendritic cells. Ebi3 may function to antagonize IL-12 and to inhibit the development of a Th1 immune response. Ebi3 is strongly expressed in Hodgkin and Reed-Sternberg cells, independently of the EBV status of the tumor cells. Research suggests that Ebi3 may be an additional component of the repertoire employed by Hodgkin and Reed-Sternberg cells to inhibit an effective anti-tumor or anti-viral immune response. The human Ebi3 gene maps to chromosome 19p13.3 and encodes a secreted glycoprotein that is expressed in spleen and tonsils, and at high levels in full-term placenta.

反应种属:

Human

宿主来源:

Mouse

实验应用:

ELISA, IHC-P

同种型:

Mouse IgG2b, kappa

免疫原:

A recombinant fragment (within amino acids 366-466) of human EBI3 protein was used as the immunogen for the EBI3 antibody.

克隆性:

Monoclonal (mouse origin)