EP4 Receptor (human) Reporter Assay Kit-比色法检测试剂盒-深圳欣博盛生物科技有限公司

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EP4 Receptor (human) Reporter Assay Kit

品牌：Cayman

官网链接

说明书

折扣/货期

货号：601390

规格：96 wells

目录价：￥6847.4

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

EP4 Receptor (human) Reporter Assay Kit

别名:

PGE2 Receptor 4|Prostaglandin E2 Receptor 4

产品描述:

PGE2 is one of the most important biologically active prostanoids which exerts its actions mainly by binding to four distinct E-type prostanoid receptors: EP1, EP2, EP3, and EP4. These four GPCRs exhibit differences in signal transduction mechanisms, tissue localization, and regulation of expression. EP4 receptors are highly expressed in the intestine, but are found in lower levels in the lung, kidney, thymus, uterus, and brain. The receptors are primarily coupled to Gs to stimulate the cAMP second messenger signal transduction pathway. EP4 receptors play important roles in relaxation of smooth muscle, gastric acid secretion, intestinal epithelial transportation, adrenal aldosterone secretion, uterine functions, bone formation, bone resorption, immunity, and inflammation. They have been suggested to involve in colorectal carcinogenesis, neuroprotection in excitotoxic brain injury, and cardiac hypertrophy. The diverse effects of PGE2 via EP4 receptors point to the need to identify novel agonists, antagonists, and modulators, both to further elucidate the function of this receptor subtype and for use as therapeutics for various diseases.

保存温度:

-20

运输温度:

-20

有效期:

365

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