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折扣/货期| 货号：AG-CR1-3634-M005 | 规格：5 mg | 目录价：￥1440 |
| 货号：AG-CR1-3634-M025 | 规格：25 mg | 目录价：￥5280 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Epacadostat
别名:
INCB24360; (E)-N’-(3-Bromo-4-fluorophenyl)-N-hydroxy-4-((2-(sulfamoylamino-1,2,5-oxadiazole-3-carboxamide)
产品描述:
Potent and selective competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. Inhibits IDO1 in enzymatic (IC50=72nM) and in cellular tests (IC50=7.1nM), suppresses tryptophan catabolism in vivo and impedes tumor growth. Displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO). Exhibits potent in vitro and in vivo immunomodulating and antineoplastic activities. By inhibiting IDO1 and decreasing kynurenine levels in tumor cells, Epacadostat increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells and T-lymphocytes, as well as interferon (IFN) production and reduces tumor-associated regulatory T cells (Tregs).
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
438.2
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
1204669-58-8
分子式:
C11H13BrFN7O4S
溶解度:
Soluble in DMSO (~30mg/ml). Insoluble in water.
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