Epacadostat-抑制剂-深圳欣博盛生物科技有限公司

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Epacadostat

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CR1-3634-M005	规格：5 mg	目录价：￥840
货号：AG-CR1-3634-M025	规格：25 mg	目录价：￥2520

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Epacadostat

别名:

INCB24360; (E)-N’-(3-Bromo-4-fluorophenyl)-N-hydroxy-4-((2-(sulfamoylamino-1,2,5-oxadiazole-3-carboxamide)

产品描述:

Potent and selective competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. Inhibits IDO1 in enzymatic (IC50=72nM) and in cellular tests (IC50=7.1nM), suppresses tryptophan catabolism in vivo and impedes tumor growth. Displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO). Exhibits potent in vitro and in vivo immunomodulating and antineoplastic activities. By inhibiting IDO1 and decreasing kynurenine levels in tumor cells, Epacadostat increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells and T-lymphocytes, as well as interferon (IFN) production and reduces tumor-associated regulatory T cells (Tregs).

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

438.2

产品形式:

solid

产地:

瑞士

纯度:

>98% (HPLC)