NVP-BEZ235-抑制剂-深圳欣博盛生物科技有限公司

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NVP-BEZ235

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CR1-3633-M005	规格：5 mg	目录价：￥300
货号：AG-CR1-3633-M025	规格：25 mg	目录价：￥780

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

NVP-BEZ235

别名:

Dactolisib; BEZ235; 4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-alpha,alpha-dimethyl-benzeneacetonitrile

产品描述:

Potent dual ATP-competitive pan class I PI3K and mTOR inhibitor (p110alpha/gamma/delta/beta and mTOR(p70S6K) with IC50 of 4nM, 5nM, 7nM, 75nM and 6nM, respectively), subsequently inducing G1 phase arrest in biological cell growth and viability assays. Anticancer compound. Antiproliferative against several animal tumor cell lines, specifically blocking the dysfunctional activation of the PI3K pathway, Enhances the efficacy of other anticancer agents when used in in vivo combination studies. Strongly inhibits VEGF-induced cell proliferation and survival in vitro and VEGF-induced angiogenesis in vivo. Shown to be a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage and DNA double-strand break repair. Shown to have neuroprotective properties on amyloid-beta 1-42 induced neurotoxicity and memory impairment. Shows anti-trypanosomal activity for some selected species.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

469.5

产品形式:

solid

产地:

瑞士

纯度:

>98%