Epoxomicin-抑制剂-深圳欣博盛生物科技有限公司

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Epoxomicin

品牌：Stressmarq

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说明书

折扣/货期

货号：SIH-388-100UG

规格：100 µg

目录价：￥3211.2

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Epoxomicin

别名:

N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-threoninamide

产品描述:

Proteasome inhibitor

保存温度:

-20ºC

运输温度:

Shipped Ambient

预期分子量:

554.7

产品形式:

White solid

产地:

加拿大

功能与背景:

Epoxomicin is a cell permeable, potent and selective proteasome inhibitor originally isolated from Actinomycetes strain based on its potent in vivo antitumor activity. It is a more potent inhibitor of the chymotrypsin-like activity of the proteasome than lactacystin. Epoxomicin also blocks trypsin-like and PGPH activities of the proteasome and regulates antigen presentation at non-toxic doses. It effectively inhibits NF-κB activation in vitro and potently blocks inflammation in vivo in the mouse ear edema assay. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus inhibition of UPS by Epoxomicin activates autophagy.

纯度:

>95%

来源:

Synthetic

CAS号:

134381-21-8

分子式:

C28H50N4O7

溶解度:

Soluble in DMSO (15 mg/ml) or dichloromethane:methanol (9:1); insoluble in water.

PubChem CID:

11226684