Fc (human):BAFF (human) (rec.)-Fc融合蛋白-深圳欣博盛生物科技有限公司

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Fc (human):BAFF (human) (rec.)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40B-0120-3010	规格：3 x 10 ug	目录价：￥4560
货号：AG-40B-0120-C010	规格：10 ug	目录价：￥2280
货号：AG-40B-0120-C500	规格：500 ug	目录价：￥26400

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Fc (human):BAFF (human) (rec.)

别名:

BLyS; TALL-1; CD257; B Cell Activating Factor; TNFSF13B; Tumor Necrosis Factor Ligand Superfamily Member 13B

产品描述:

BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers.

宿主来源:

CHO cells

靶标/特异性:

Binds to human and mouse BAFF-R, TACI and BCMA.

产品浓度:

After reconstitution:for 10µg size: 0.1mg/mlfor 500µg size: 1 mg/ml

保存温度:

+4°C

运输温度:

预期分子量:

~50kDa (SDS-PAGE; reducing conditions)~100kDa (SDS-PAGE; non-reducing conditions)~300kDa (SDS-PAGE; native conditions; multimerizes and forms hexamers)

产品形式:

solid

存储溶液:

Lyophilized. Contains PBS.

产地:

瑞士

纯度:

>95% (SDS-PAGE)

生物活性:

Rescues the production of mature follicular and marginal zone B cells. - in vitro: Addition of 1-100 ng/ml of Fc-BAFF induces B cell survival in a dose-dependent manner. - in vivo: Fc-BAFF treatment rescues mature B cell development in BAFF deficient mice. Mice are injected at day 0 with 100 µg Fc-BAFF i.v. and at day 14 with 50 µg Fc-BAFF i.p.

内毒素水平:

<0.01EU/µg purified protein (LAL test; Lonza).

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